PT-141 (Bremelanotide) 10 MG

Investigate melanocortin signaling in the central nervous system.

PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide derived from alpha-melanocyte-stimulating hormone (α-MSH). It acts as a melanocortin receptor agonist with primary activity at the MC3 and MC4 receptors, which are expressed throughout the hypothalamus and other regions of the brain.

PT-141 is closely related to Melanotan II and is considered an active metabolite of that peptide, differing by a free carboxylic acid in place of the C-terminal amide. Because it acts through central melanocortin pathways rather than vascular mechanisms, it gives researchers a distinct tool for studying how the brain regulates motivation and arousal.

Key Research Areas

• Melanocortin receptor signaling: Investigation of MC3R and MC4R activation and downstream signaling in hypothalamic models.
• Central pathways of sexual behavior: Exploration of brain-mediated mechanisms of sexual motivation and arousal, separate from the blood-flow pathways targeted by PDE5 inhibitors.
• Peptide structure–activity research: Comparison of cyclic α-MSH analogues, including PT-141 and Melanotan II, and their receptor selectivity.

Product Information

• Compound: PT-141 (Bremelanotide)
• Amount: 10 MG per vial
• Classification: Synthetic cyclic melanocortin receptor agonist
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• Molecular formula: C₅₀H₆₈N₁₄O₁₀
• Molecular weight: 1025.2 g/mol
• CAS number: 189691-06-3
• Form: Lyophilized powder
• Brand: Tip Of The Spear Research

Storage and Handling

Store sealed vials in a cool, dry place away from light; lyophilized peptides are typically kept at -20 °C for longer-term storage. Follow the supplier’s product-specific storage instructions and applicable laboratory handling procedures. Confirm formulation, identity, purity, and assay suitability using available batch documentation before research use.

Research Use Only

This product is intended exclusively for laboratory research. Not for human or animal use. Research topics describe areas of scientific investigation and do not represent promised outcomes from this product.