Kisspeptin-10 10 MG

Study the signal at the top of the reproductive hormone axis.

Kisspeptin-10 is a ten-amino acid peptide corresponding to residues 45–54 of kisspeptin, the protein encoded by the KISS1 gene. It is the shortest kisspeptin fragment that retains full activity at the kisspeptin receptor, KISS1R (also known as GPR54), a G-protein-coupled receptor found on hypothalamic GnRH neurons.

Kisspeptin signaling is studied as a key upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Activation of KISS1R stimulates the release of gonadotropin-releasing hormone (GnRH), which in turn drives luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion from the pituitary. The kisspeptin family was first identified in cancer research as a metastasis suppressor, which is why Kisspeptin-10 is also known as metastin (45–54).

Key Research Areas

• KISS1R (GPR54) signaling: Investigation of receptor binding and G-protein-coupled signaling in hypothalamic models.
• GnRH and gonadotropin release: Exploration of LH and FSH secretion dynamics across the HPG axis.
• Neuroendocrine regulation: Research into puberty onset, reproductive cycling, and how metabolic signals connect to reproductive function.

Product Information

• Compound: Kisspeptin-10 (Metastin 45–54, KP-10)
• Amount: 10 MG per vial
• Classification: Kisspeptin receptor (KISS1R / GPR54) agonist peptide
• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (YNWNSFGLRF-NH₂)
• Molecular formula: C₆₃H₈₃N₁₇O₁₄
• Molecular weight: 1302.5 g/mol
• CAS number: 374675-21-5
• Form: Lyophilized powder
• Brand: Tip Of The Spear Research

Storage and Handling

Store sealed vials in a cool, dry place away from light; lyophilized peptides are typically kept at -20 °C for longer-term storage. Follow the supplier’s product-specific storage instructions and applicable laboratory handling procedures. Confirm formulation, identity, purity, and assay suitability using available batch documentation before research use.

Research Use Only

This product is intended exclusively for laboratory research. Not for human or animal use. Research topics describe areas of scientific investigation and do not represent promised outcomes from this product.